Conditioned suppression and self-stimulation

Chronic WIN55,212-2 elicits sustained and conditioned increases in intracranial self-stimulation thresholds in the rat.

The present study sought to examine whether repeated administration of the CB(1) receptor agonist WIN55,212-2 affected intracranial self-stimulation (ICSS) behavior and induced phenomena of tolerance or sensitization, similar to typical addictive drugs. Rats received intraperitoneal injections of vehicle for 5 days, vehicle or WIN55,212-2 (0.1, 0.3 or 1mg/kg) for 20 subsequent days, and vehicle...

Rats’ location during conditioned suppression training

Familiarity-Based Stimulus Generalization of Conditioned Suppression

We report that stimulus novelty/familiarity is able to modulate stimulus generalization and discuss the theoretical implications of novelty/familiarity coding. Rats in Skinner boxes received clicker → shock pairings before generalization testing to a tone. Before clicker training, different groups of rats received preexposure treatments designed to systematically modulate the clicker and the to...

DESIGN AND STRUCTURE OF A NEW DEVICE FOR AUDITORY ELECTRICAL STIMULATION FOR SUPPRESSION OF TINNITUS

Auditory Electrical Stimulation for Tinnitus Suppression Tinnitus is the conscious experience of sound which arises in the head of its owner, but without a voluntary origin obvious to that person. About 10-15% of all adults report prolonged spontaneous tinnitus (PST). There are a lot of methods for suppressing this complaint. One of these methods is electrical stimulation. Electrical stimu...

Intermittent stimulation enhances function of conditioned muscle.

Skeletal muscle is highly adaptable in that its metabolic and contractile characteristics are largely regulated by its pattern of use. It is known that muscle phenotype can be manipulated via chronic electrical stimulation to enhance fatigue resistance at the expense of contractile power. Type 2A fibers are fatigue resistant, powerful, and considered most desirable for cardiac assist purposes. ...